Cell cycle-dependent degradation of the methyltransferase SETD3 attenuates cell proliferation and liver tumorigenesis.

Cheng, Xiaoqing; Hao, Yuan; Shu, Wenjie; Zhao, Mengjie; Zhao, Chen; Wu, Yuan; Peng, Xiaodan; Yao, Pinfang; Xiao, Daibiao; Qing, Guoliang; Pan, Zhengying; Yin, Lei; Hu, Desheng; Du, Hai-Ning

Cheng, Xiaoqing; Hao, Yuan; Shu, Wenjie; Zhao, Mengjie; Zhao, Chen; Wu, Yuan; Peng, Xiaodan; Yao, Pinfang; Xiao, Daibiao; Qing, Guoliang; Pan, Zhengying; Yin, Lei; Hu, Desheng; Du, Hai-Ning.

Afiliação

Cheng X; From the Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072.
Hao Y; the Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiaotong University School of Medicine, Shanghai 200092, haoyuan@medmail.com.cn.
Shu W; From the Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072.
Zhao M; From the Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072.
Zhao C; From the Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072.
Wu Y; the Department of Radiotherapy, Hubei Cancer Hospital, Wuhan 430079.
Peng X; the Department of Oncology, Shenzhen Hospital of Peking University, Shenzhen 518083.
Yao P; the Department of Radiotherapy, Hubei Cancer Hospital, Wuhan 430079.
Xiao D; the Medical Research Institute, Wuhan University, Wuhan 430071, and.
Qing G; the Medical Research Institute, Wuhan University, Wuhan 430071, and.
Pan Z; the Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen 518055, China.
Yin L; From the Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072.
Hu D; the Department of Radiotherapy, Hubei Cancer Hospital, Wuhan 430079, hds_05@163.com.
Du HN; From the Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, hainingdu@whu.edu.cn.

J Biol Chem ; 292(22): 9022-9033, 2017 06 02.

Article em En | MEDLINE | ID: mdl-28442573

Assuntos

Proliferação de Células; Transformação Celular Neoplásica/metabolismo; Histona-Lisina N-Metiltransferase/metabolismo; Neoplasias Hepáticas Experimentais/metabolismo; Proteínas de Neoplasias/metabolismo; Proteólise; Substituição de Aminoácidos; Animais; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Transformação Celular Neoplásica/genética; Transformação Celular Neoplásica/patologia; Proteínas F-Box/genética; Proteínas F-Box/metabolismo; Proteína 7 com Repetições F-Box-WD; Glicogênio Sintase Quinase 3 beta/genética; Glicogênio Sintase Quinase 3 beta/metabolismo; Células HeLa; Xenoenxertos; Histona Metiltransferases; Histona-Lisina N-Metiltransferase/genética; Humanos; Neoplasias Hepáticas Experimentais/genética; Neoplasias Hepáticas Experimentais/patologia; Camundongos; Camundongos Nus; Mutação de Sentido Incorreto; Proteínas de Neoplasias/genética; Transplante de Neoplasias; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

cell cycle; cell proliferation; liver cancer; methyltransferase; protein degradation; protein phosphorylation; protein stability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / Histona-Lisina N-Metiltransferase / Proliferação de Células / Proteólise / Neoplasias Hepáticas Experimentais / Proteínas de Neoplasias Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

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