Susceptibility of Plasmodium falciparum to a peroxidase-mediated oxygen-dependent microbicidal system.
Infect Immun
; 56(12): 3305-9, 1988 Dec.
Article
em En
| MEDLINE
| ID: mdl-2846444
ABSTRACT
The viability of Plasmodium falciparum in culture was assessed by [3H]hypoxanthine incorporation during 24 h of incubation with lactoperoxidase, glucose-glucose oxidase, hydrogen peroxide, halides, or thiocyanate, alone or in combination. Synergistic inhibition was produced by the following combinations lactoperoxidase plus hydrogen peroxide, lactoperoxidase plus glucose-glucose oxidase, and lactoperoxidase plus hydrogen peroxide plus halides or thiocyanate. These inhibitory effects were reversed by catalase and glutathione. The presence of plasmodial crisis forms inside the erythrocytes suggests that the oxygen-dependent microbicidal system of phagocytes has a killing effect.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Plasmodium falciparum
Limite:
Animals
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
França