Pregnane steroids from the Vietnamese octocoral Carijoa riisei.
Nat Prod Res
; 31(20): 2435-2440, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28480737
ABSTRACT
Six pregnane steroids including one new compound namely 15ß-hydroxypregna-4,20-dien-3-one (1), were isolated and structurally elucidated from the octocoral Carijoa riisei. The cytotoxic activity against a panel of eight human cancer cell lines of isolated compounds was also evaluated by SRB method. As the results, 18-acetoxypregna-1,4,20-trien-3-one (5) showed significant cytotoxicity against all the tested cell lines with the IC50 values from 22.29 ± 1.47 to 48.73 ± 3.93 µM, whereas 15ß-acetoxypregna-1,4,20-trien-3-one (3) and 20R-acetoxypregna-1,4-dien-3-one (6) only exhibited weak effect on KB cell line with IC50 values of 93.62 ± 7.32 and 71.38 ± 5.45 µM, respectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pregnanos
/
Esteroides
/
Antozoários
/
17-alfa-Hidroxipregnenolona
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Vietnã