The microcirculation: a key player in obesity-associated cardiovascular disease.
Cardiovasc Res
; 113(9): 1035-1045, 2017 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-28482008
It is increasingly recognized that obesity is a risk factor for microvascular disease, involving both structural and functional changes in the microvasculature. This review aims to describe how obesity impacts the microvasculature of a variety of tissues, including visceral adipose tissue, skeletal muscle, heart, brain, kidneys, and lungs. These changes involve endothelial dysfunction, which in turn (i) impacts control of vascular tone, (ii) contributes to development of microvascular insulin resistance, (iii) alters secretion of paracrine factors like nitric oxide and endothelin, but (iv) also influences vascular structure and perivascular inflammation. In concert, these changes impair organ perfusion and organ function thereby contributing to altered release and clearance of neurohumoral factors, such as adipokines and inflammatory cytokines. Global microvascular dysfunction in obese subjects is therefore a common pathway that not only explains exercise-intolerance but also predisposes to development of chronic kidney disease, microvascular dementia, coronary microvascular angina, heart failure with preserved ejection fraction, chronic obstructive pulmonary disease, and pulmonary hypertension.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Doenças Cardiovasculares
/
Tecido Adiposo
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Músculo Esquelético
/
Vasos Coronários
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Microvasos
/
Hemodinâmica
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Rim
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Pulmão
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Microcirculação
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cardiovasc Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Holanda
País de publicação:
Reino Unido