Tuberculosis in adolescents and young adults: epidemiology and treatment outcomes in the Western Cape.
Int J Tuberc Lung Dis
; 21(6): 651-657, 2017 06 01.
Article
em En
| MEDLINE
| ID: mdl-28482959
ABSTRACT
SETTING:
Western Cape Province, South Africa.OBJECTIVES:
To characterise tuberculosis (TB) epidemiology, disease presentation and treatment outcomes among adolescents (age 10-19 years) and young adults (age 20-24 years) in the Western Cape.DESIGN:
A retrospective, cross-sectional review of routine patient-level data from the Electronic TB Register (ETR.Net) for 2013. Site of TB disease, human immunodeficiency virus (HIV) status and TB treatment outcomes were analysed by 5-year age groups (<5, 5-9, 10-14, 15-19, 20-24 and î¶25 years of age). TB notification rates were calculated using census data.RESULTS:
Adolescents and young adults comprised 18.0% of all new TB notifications in 2013. The notification rate was 141 TB cases/100 000 person-years (py) among 10-14 year olds, 418/100 000 py among 15-19 year olds and 627/100 000 py among 20-24 year olds. HIV prevalence among TB patients was 10.9% in 10-14 year olds, 8.8% in 15-19 year olds and 27.2% in 20-24 year olds. Older adolescents (age 15-19 years) and young adults (age 20-24 years) with HIV co-infection had poor treatmentoutcomes:
15.6% discontinued treatment prematurely and 4.0% died.CONCLUSIONS:
Young people in the Western Cape suffer a substantial burden of TB, and those with TB-HIV co-infection are at high risk of treatment discontinuation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Infecções por HIV
/
Notificação de Doenças
/
Antituberculosos
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Austrália