A new class of free radical scavengers reducing adriamycin mitochondrial toxicity.
Biochem Pharmacol
; 37(24): 4617-22, 1988 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-2849451
ABSTRACT
Beef heart mitochondria were incubated with ADM and NADH. An adriamycin semiquinone radical was detected using ESR spectroscopy. The semiquinone radical production rate is decreased upon addition of a scavenger (AD 20) in the reaction medium. NMRI mice were treated with AD 20 (70 mg/kg, i.p.) 15 min prior ADM injection (20 mg/kg, i.p.) or with ADM alone. Heart mitochondria were isolated 48 hr later. The enzymatic activities of complex I-III and complex IV of the mitochondrial respiratory chain were strongly depressed in animals receiving ADM alone, whereas these activities were almost completely restored in animals receiving AD 20 and ADM. Fluorescence depolarization measurements indicated that only mice treated with ADM alone presented a decreased fluidity of their cardiac mitochondrial membrane.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
/
Alanina
/
Radicais Livres
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Bélgica
País de publicação:
ENGLAND
/
ESCOCIA
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GB
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GREAT BRITAIN
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INGLATERRA
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REINO UNIDO
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SCOTLAND
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UK
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UNITED KINGDOM