Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling.

Jeayeng, Saowanee; Wongkajornsilp, Adisak; Slominski, Andrzej T; Jirawatnotai, Siwanon; Sampattavanich, Somponnat; Panich, Uraiwan

Jeayeng, Saowanee; Wongkajornsilp, Adisak; Slominski, Andrzej T; Jirawatnotai, Siwanon; Sampattavanich, Somponnat; Panich, Uraiwan.

Afiliação

Jeayeng S; Siriraj Laboratory for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Wongkajornsilp A; Siriraj Laboratory for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Slominski AT; Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham,
Jirawatnotai S; Siriraj Laboratory for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Sampattavanich S; Siriraj Laboratory for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Panich U; Siriraj Laboratory for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Electronic address: uraiwan.pan@mahidol.ac.th.

Free Radic Biol Med ; 108: 918-928, 2017 07.

Article em En | MEDLINE | ID: mdl-28495448

Assuntos

Queratinócitos/fisiologia; Melanócitos/fisiologia; Fator 2 Relacionado a NF-E2/metabolismo; Apoptose; Células Cultivadas; Técnicas de Cocultura; Dano ao DNA; Humanos; Sistema de Sinalização das MAP Quinases; Fator 2 Relacionado a NF-E2/genética; Estresse Oxidativo; Comunicação Parácrina; Cultura Primária de Células; Dímeros de Pirimidina/metabolismo; RNA Interferente Pequeno/genética; Transdução de Sinais; Raios Ultravioleta; alfa-MSH/metabolismo

Palavras-chave

Apoptosis; Keratinocytes; Melanocytes; Nuclear factor E2-related factor 2 (Nrf2); Reactive oxygen species (ROS); Ultraviolet B

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queratinócitos / Fator 2 Relacionado a NF-E2 / Melanócitos Limite: Humans Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Tailândia País de publicação: Estados Unidos

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