Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs.
Antimicrob Agents Chemother
; 61(8)2017 08.
Article
em En
| MEDLINE
| ID: mdl-28507115
ABSTRACT
White and opaque cells of Candida albicans have the same genome but differ in gene expression patterns, metabolic profiles, and host niche preferences. We tested whether these differences, which include the differential expression of drug transporters, resulted in different sensitivities to 27 antifungal agents. The analysis was performed in two different strain backgrounds; although there was strain-to-strain variation, only terbinafine hydrochloride and caspofungin showed consistent, 2-fold differences between white and opaque cells across both strains.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Candidíase
/
Regulação Fúngica da Expressão Gênica
/
Antifúngicos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos