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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Llona-Minguez, Sabin; Höglund, Andreas; Ghassemian, Artin; Desroses, Matthieu; Calderón-Montaño, José Manuel; Burgos Morón, Estefanía; Valerie, Nicholas C K; Wiita, Elisee; Almlöf, Ingrid; Koolmeister, Tobias; Mateus, André; Cazares-Körner, Cindy; Sanjiv, Kumar; Homan, Evert; Loseva, Olga; Baranczewski, Pawel; Darabi, Masoud; Mehdizadeh, Amir; Fayezi, Shabnam; Jemth, Ann-Sofie; Warpman Berglund, Ulrika; Sigmundsson, Kristmundur; Lundbäck, Thomas; Jenmalm Jensen, Annika; Artursson, Per; Scobie, Martin; Helleday, Thomas.
Afiliação
  • Llona-Minguez S; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Höglund A; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Ghassemian A; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Desroses M; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Calderón-Montaño JM; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Burgos Morón E; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Valerie NCK; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Wiita E; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Almlöf I; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Koolmeister T; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Mateus A; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Science for Life Laboratory, Uppsala University , Uppsala 752 37, Sweden.
  • Cazares-Körner C; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Sanjiv K; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Homan E; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Loseva O; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Baranczewski P; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Science for Life Laboratory, Uppsala University , Uppsala 752 37, Sweden.
  • Darabi M; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz 5165665931, Iran.
  • Mehdizadeh A; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz 5165665931, Iran.
  • Fayezi S; Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences , Tehran 1983969411, Iran.
  • Jemth AS; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Warpman Berglund U; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Sigmundsson K; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Lundbäck T; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Jenmalm Jensen A; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Artursson P; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Scobie M; Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
  • Helleday T; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm 171 65, Sweden.
J Med Chem ; 60(10): 4279-4292, 2017 05 25.
Article em En | MEDLINE | ID: mdl-28508636
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Piridazinas / Pirofosfatases / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suécia País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Piridazinas / Pirofosfatases / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suécia País de publicação: Estados Unidos