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Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.
Howson, Joanna M M; Zhao, Wei; Barnes, Daniel R; Ho, Weang-Kee; Young, Robin; Paul, Dirk S; Waite, Lindsay L; Freitag, Daniel F; Fauman, Eric B; Salfati, Elias L; Sun, Benjamin B; Eicher, John D; Johnson, Andrew D; Sheu, Wayne H H; Nielsen, Sune F; Lin, Wei-Yu; Surendran, Praveen; Malarstig, Anders; Wilk, Jemma B; Tybjærg-Hansen, Anne; Rasmussen, Katrine L; Kamstrup, Pia R; Deloukas, Panos; Erdmann, Jeanette; Kathiresan, Sekar; Samani, Nilesh J; Schunkert, Heribert; Watkins, Hugh; Do, Ron; Rader, Daniel J; Johnson, Julie A; Hazen, Stanley L; Quyyumi, Arshed A; Spertus, John A; Pepine, Carl J; Franceschini, Nora; Justice, Anne; Reiner, Alex P; Buyske, Steven; Hindorff, Lucia A; Carty, Cara L; North, Kari E; Kooperberg, Charles; Boerwinkle, Eric; Young, Kristin; Graff, Mariaelisa; Peters, Ulrike; Absher, Devin; Hsiung, Chao A; Lee, Wen-Jane.
Afiliação
  • Howson JMM; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Zhao W; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Barnes DR; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Ho WK; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Young R; Department of Applied Mathematics, University of Nottingham Malaysia Campus, Semenyih, Malaysia.
  • Paul DS; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Waite LL; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
  • Freitag DF; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Fauman EB; HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA.
  • Salfati EL; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Sun BB; Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.
  • Eicher JD; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
  • Johnson AD; Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.
  • Sheu WHH; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Nielsen SF; National Heart, Lung, and Blood Institute, Population Sciences Branch, Bethesda, Maryland, USA.
  • Lin WY; NHLBI and Boston University's The Framingham Heart Study, Framingham, Massachusetts, USA.
  • Surendran P; National Heart, Lung, and Blood Institute, Population Sciences Branch, Bethesda, Maryland, USA.
  • Malarstig A; NHLBI and Boston University's The Framingham Heart Study, Framingham, Massachusetts, USA.
  • Wilk JB; Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Tybjærg-Hansen A; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Rasmussen KL; College of Medicine, National Defense Medical Center, Taipei, Taiwan.
  • Kamstrup PR; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Deloukas P; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Erdmann J; Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.
  • Kathiresan S; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Samani NJ; Pfizer Worldwide Research and Development, Stockholm, Sweden.
  • Schunkert H; Pfizer Worldwide Research and Development, Human Genetics, Cambridge, Massachusetts, USA.
  • Watkins H; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Do R; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Rader DJ; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Johnson JA; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Hazen SL; Centre for Genomic Health, Queen Mary University of London, London, UK.
  • Quyyumi AA; Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
  • Spertus JA; DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany.
  • Pepine CJ; University Heart Center Lübeck, Lübeck, Germany.
  • Franceschini N; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Justice A; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Reiner AP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Buyske S; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • Hindorff LA; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
  • Carty CL; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • North KE; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Kooperberg C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Young K; Charles Bronfman Institute for Personalized Medicine, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Graff M; Departments of Genetics, Medicine, and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Peters U; University of Florida College of Pharmacy, Gainesville, Florida, USA.
  • Absher D; Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, Ohio, USA.
  • Hsiung CA; Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Lee WJ; Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.
Nat Genet ; 49(7): 1113-1119, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28530674
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias / Doença da Artéria Coronariana / Estudo de Associação Genômica Ampla Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias / Doença da Artéria Coronariana / Estudo de Associação Genômica Ampla Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos