Hallmarks of Treatment Aspects: Parkinson's Disease Throughout Centuries Including l-Dopa.
Int Rev Neurobiol
; 132: 295-343, 2017.
Article
em En
| MEDLINE
| ID: mdl-28554412
ABSTRACT
Deficit of striatal dopamine was first discovered in postmortem brain of patients with Parkinson's disease in 1960. This observation was the starting point for dopamine replacement therapy, and successful introduction of high dose l-dopa therapy in the 1969 revolutionized the treatment of Parkinson's disease. Since then, constant attempts have been made to enhance the efficacy of l-dopa and reduce motor complications by providing more continuous dopamine stimulation. This chapter traces the hallmarks of medical treatments for Parkinson's disease throughout centuries including the first description of antiparkinsonian effects of anticholinergics, the birth of apomorphine in the 1900s, then discovery of l-dopa in the 1960s, and development of dopamine agonists since the 1970s.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Levodopa
/
Agonistas de Dopamina
/
Antagonistas Colinérgicos
/
Antiparkinsonianos
Limite:
Humans
Idioma:
En
Revista:
Int Rev Neurobiol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Coréia do Sul