Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases.
Pathol Res Pract
; 213(8): 1002-1009, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28559118
ABSTRACT
INTRODUCTION:
Recently TRG, necrosis grade and the rate of viable cancer cells of colorectal liver metastases were correlated with the response to chemotherapy treatments, whereas K-RAS mutations and c-MET over-expression were correlated with the prognosis.METHODS:
58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly. We investigated the K-RAS mutational profile, the c-MET over-expression along with patients' survivals curves.RESULTS:
Patients undergone neo-adjuvant treatment presented significant higher fibrosis rates and lower rates of viable cells. 36.7% of the patients had a K-RAS mutation and the 26.7% presented c-MET over-expression, but these features did not correlate with patients' clinical/pathological data. Survival analysis documented that K-RAS WT patients presenting c-MET over-expression had worse outcomes.CONCLUSION:
Fibrosis and the rate of viable cells significantly correlate with the response to chemotherapy treatments. c-MET is a promising marker in K-RAS WT patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
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Adenocarcinoma
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Proteínas Proto-Oncogênicas p21(ras)
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Proteínas Proto-Oncogênicas c-met
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Neoplasias Hepáticas
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Pathol Res Pract
Ano de publicação:
2017
Tipo de documento:
Article