A retrospective study of anti-inflammatory use in dogs with pulmonary blastomycosis: 139 cases (2002-2012).
J Vet Emerg Crit Care (San Antonio)
; 27(4): 439-443, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28561957
ABSTRACT
OBJECTIVE:
To determine the effect of anti-inflammatory medications on 30-day survival of dogs treated for pulmonary blastomycosis.DESIGN:
Retrospective study.SETTING:
University teaching hospital. ANIMALS One hundred thirty nine client-owned dogs with confirmed pulmonary blastomycosis. MEASUREMENTS AND MAINRESULTS:
The medical records of dogs diagnosed with pulmonary blastomycosis between May 2002 and October 2012 were identified. Of 139 dogs, 85 (61%) survived to 30 days, 38 (27%) were euthanized due to progressive clinical disease, 13 (10%) died secondary to respiratory or cardiac arrest, and 3 (2%) did not survive to 30 days but had an unknown cause of death. Cases were classified based on the anti-inflammatory therapy that was used nonsteroidal anti-inflammatory drugs (NSAID), corticosteroids, both, or none. Controlling for the effects of itraconazole dose, sex, age, and pretreatment with anti-inflammatory medication, the odds for survival to 30 days was not statistically different between dogs who received no anti-inflammatory medication and the dogs who received NSAIDs (P = 0.86), corticosteroids (P = 0.65), or both (P = 0.27). The need for supplemental oxygen was associated with decreased survival (P < 0.0001).CONCLUSIONS:
In this population of dogs with pulmonary blastomycosis, the use of anti-inflammatory medications during therapy did not impact 30-day survival; however, the need for oxygen supplementation was associated with significantly lower survival.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Blastomicose
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Anti-Inflamatórios não Esteroides
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Doenças do Cão
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Pneumopatias Fúngicas
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Vet Emerg Crit Care (San Antonio)
Assunto da revista:
MEDICINA DE EMERGENCIA
/
MEDICINA VETERINARIA
/
TERAPIA INTENSIVA
Ano de publicação:
2017
Tipo de documento:
Article