G protein-coupled receptor 84 controls osteoclastogenesis through inhibition of NF-&#954;B and MAPK signaling pathways.

Park, Ji-Wan; Yoon, Hye-Jin; Kang, Woo Youl; Cho, Seungil; Seong, Sook Jin; Lee, Hae Won; Yoon, Young-Ran; Kim, Hyun-Ju

G protein-coupled receptor 84 controls osteoclastogenesis through inhibition of NF-κB and MAPK signaling pathways.

Park, Ji-Wan; Yoon, Hye-Jin; Kang, Woo Youl; Cho, Seungil; Seong, Sook Jin; Lee, Hae Won; Yoon, Young-Ran; Kim, Hyun-Ju.

Afiliação

Park JW; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Yoon HJ; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Kang WY; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Cho S; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Seong SJ; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Lee HW; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Yoon YR; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Kim HJ; Department of Biomedical Science, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, Clinical Trial Center, School of Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.

J Cell Physiol ; 233(2): 1481-1489, 2018 Feb.

Article em En | MEDLINE | ID: mdl-28574596

Assuntos

Proteínas Quinases Ativadas por Mitógeno/metabolismo; NF-kappa B/metabolismo; Osteoclastos/enzimologia; Osteogênese; Receptores Acoplados a Proteínas G/metabolismo; Animais; Diferenciação Celular; Regulação da Expressão Gênica; Camundongos; Camundongos Endogâmicos C57BL; Inibidor de NF-kappaB alfa/genética; Inibidor de NF-kappaB alfa/metabolismo; Fatores de Transcrição NFATC/genética; Fatores de Transcrição NFATC/metabolismo; Fosforilação; Proteínas Proto-Oncogênicas c-fos/genética; Proteínas Proto-Oncogênicas c-fos/metabolismo; Ligante RANK/genética; Ligante RANK/metabolismo; Células RAW 264.7; Interferência de RNA; Receptores Acoplados a Proteínas G/genética; Transdução de Sinais; Fatores de Tempo; Transfecção

Palavras-chave

GPR84; NF-κB; NFATc1; c-Fos; osteoclastogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Osteogênese / NF-kappa B / Proteínas Quinases Ativadas por Mitógeno / Receptores Acoplados a Proteínas G Limite: Animals Idioma: En Revista: J Cell Physiol Ano de publicação: 2018 Tipo de documento: Article

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