The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-ß antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation.

Ding, Zhen; Fang, Liurong; Yuan, Shuangling; Zhao, Ling; Wang, Xunlei; Long, Siwen; Wang, Mohan; Wang, Dang; Foda, Mohamed Frahat; Xiao, Shaobo

Ding, Zhen; Fang, Liurong; Yuan, Shuangling; Zhao, Ling; Wang, Xunlei; Long, Siwen; Wang, Mohan; Wang, Dang; Foda, Mohamed Frahat; Xiao, Shaobo.

Afiliação

Ding Z; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Fang L; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Yuan S; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Zhao L; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Wang X; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Long S; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Wang M; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Wang D; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
Foda MF; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Xiao S; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.

Oncotarget ; 8(30): 49655-49670, 2017 Jul 25.

Article em En | MEDLINE | ID: mdl-28591694

Assuntos

Proteínas do Nucleocapsídeo/metabolismo; Animais; Linhagem Celular; Proteínas do Nucleocapsídeo de Coronavírus; Proteína DEAD-box 58/metabolismo; Humanos; Helicase IFIH1 Induzida por Interferon/metabolismo; Interferon beta/biossíntese; Interferon beta/genética; Interferon beta/metabolismo; Camundongos; Vírus da Hepatite Murina/fisiologia; Regiões Promotoras Genéticas; Ligação Proteica; RNA de Cadeia Dupla/metabolismo; Vírus Sendai/fisiologia; eIF-2 Quinase/metabolismo

Palavras-chave

PACT; coronavirus; innate immunity evasion; nucleocapsid protein; type I interferon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Nucleocapsídeo Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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