Prostaglandin E1 inhibits calcium-dependent potentials in mammalian sympathetic neurons.
Brain Res
; 334(2): 325-9, 1985 May 20.
Article
em En
| MEDLINE
| ID: mdl-2859915
ABSTRACT
Prostaglandin E1 (PGE1, 10-500 nM) reversibly depressed 3 types of calcium-dependent potentials associated with the spike potential of rabbit superior cervical ganglion cells, namely, the spike after-hyperpolarization, the post-tetanic hyperpolarization, and the Ca2+ spike evoked in a Na+-free/high Ca2+ solution. The results suggest that PGE1 reduces Ca conductance and that this action may underlie its inhibitory action on transmitter release at adrenergic and cholinergic nerve terminals.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prostaglandinas E
/
Cálcio
/
Gânglios Simpáticos
/
Potenciais da Membrana
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1985
Tipo de documento:
Article