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Ficus septica plant extracts for treating Dengue virus in vitro.
Huang, Nan-Chieh; Hung, Wan-Ting; Tsai, Wei-Lun; Lai, Feng-Yi; Lin, You-Sheng; Huang, Mei-Shu; Chen, Jih-Jung; Lin, Wei-Yu; Weng, Jing-Ru; Chang, Tsung-Hsien.
Afiliação
  • Huang NC; Department of Family Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
  • Hung WT; Section of critical care medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan.
  • Tsai WL; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Lai FY; Deparment of Nursing, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan.
  • Lin YS; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Huang MS; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
  • Chen JJ; Faculty of Pharmacy, National Yang-Ming University, Taipei, Taiwan.
  • Lin WY; Department of Pharmacy, Kinmen Hospital, Kinmen, Taiwan.
  • Weng JR; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
  • Chang TH; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
PeerJ ; 5: e3448, 2017.
Article em En | MEDLINE | ID: mdl-28607841
ABSTRACT
Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the Flaviviridae. DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, we tested 59 crude extracts, without cytotoxicity, from 23 plants in vitro; immunofluorescence assay revealed that the methanol extracts of fruit, heartwood, leaves and stem from Ficus septica Burm. f. had a promising anti-DENV-1 and DENV-2 effect. However, infection with the non-envelope picornavirus, Aichi virus, was not inhibited by treatment with F. septica extracts. F. septica may be a candidate antiviral drug against an enveloped virus such as DENV.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: PeerJ Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Taiwan
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: PeerJ Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Taiwan