Highly Diastereoselective &#945;-Arylation of Cyclic Nitriles.

Dalziel, Michael E; Chen, Penghao; Carrera, Diane E; Zhang, Haiming; Gosselin, Francis

Highly Diastereoselective α-Arylation of Cyclic Nitriles.

Dalziel, Michael E; Chen, Penghao; Carrera, Diane E; Zhang, Haiming; Gosselin, Francis.

Afiliação

Dalziel ME; Department of Small Molecule Process Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Chen P; Department of Small Molecule Process Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Carrera DE; Department of Small Molecule Process Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Zhang H; Department of Small Molecule Process Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Gosselin F; Department of Small Molecule Process Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

Org Lett ; 19(13): 3446-3449, 2017 07 07.

Article em En | MEDLINE | ID: mdl-28616988

RESUMO

A highly diastereoselective α-arylation of cyclic nitriles has been developed via a Negishi cross-coupling of commercially available aryl, heteroaryl, and alkenyl halides with cyclobutyl nitriles in the presence of tetramethylpiperidinylzinc chloride lithium chloride (TMPZnClâ¢LiCl) and catalytic XPhos-Pd-G2. A variety of electronically diverse electrophiles were well tolerated, and this chemistry was further advanced with application of both cyclopropyl and cyclopentyl nitriles.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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