C-Alkylpiperazines structurally related to piribedil. XI.
Farmaco Sci
; 40(7): 477-85, 1985 Jul.
Article
em En
| MEDLINE
| ID: mdl-2864284
ABSTRACT
The synthesis of a new series of 1-alkoxybenzyl-4-(2-pyrimidyl)piperazines 2-methyl or 2,6-dimethyl substituted, related to piribedil, is described. Besides compounds (IV)-(IX a, b), the isomer (XI) of (V) was also prepared. Central dopaminergic and alpha-blocking activities both in vitro and in vivo were determined for all compounds. Derivatives (IV), (VII), (XI) were also studied for peripheral vasodilator and sympatholytic activities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
Limite:
Animals
Idioma:
En
Revista:
Farmaco Sci
Ano de publicação:
1985
Tipo de documento:
Article
País de publicação:
IT
/
ITALIA
/
ITALY
/
ITÁLIA