NSAIDs ameliorate cognitive and motor impairment in a model of parkinsonism induced by chlorpromazine.

ABSTRACT

Parkinson's disease (PD) is a long-lasting neurodegenerative brain disease. It is characterized by a gradual decline in motor and non motor symptoms especially postural instability, tremors and memory impairment with localized loss of neurons mainly in the Substantia nigra. In the current research we evaluated the effects of Non-steroidal anti inflammatory drugs (NSAIDs) on motor coordination and memory in chlorpromazine (CPZ) induced Parkinson's experimental model. Intraperitoneal (i.p.) injection of CPZ (3 mg/kg) was given to all rats for 21 days to induce Parkinson like symptoms; ibuprofen (40mg/kg/day) and celecoxib (20mg/kg) were administered 30 minutes after CPZ injection. Behavioral parameters like Catalepsy, muscle strength (wire hanging test), locomotor activity (open field test) were observed. Moreover, its effect on memory was explored by the use of water maze and passive avoidance test. Our results showed CPZ significantly induced motor fluctuation and cognitive impairment in a period of 21 days. Celecoxib and ibuprofen significantly improved cataleptic scores (P<0.01), locomotion and muscular coordination in open field (P<0.01) and in wire hanging test (P<0.01). Significant improvement in memory was observed with celecoxib (P<0.01) and ibuprofen (P<0.05) in water maze test as well as in passive avoidance test. Therefore, the present study showed neuroprotective and memory enhancing effect of ibuprofen and celecoxib against CPZ induced Parkinson's model.