MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin.
Biomater Sci
; 5(9): 1746-1750, 2017 Aug 22.
Article
em En
| MEDLINE
| ID: mdl-28657073
ABSTRACT
Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd(iii)). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Platina
/
Porfirinas
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Imageamento por Ressonância Magnética
/
Gadolínio
Limite:
Animals
Idioma:
En
Revista:
Biomater Sci
Ano de publicação:
2017
Tipo de documento:
Article