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The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.
Treiber, Alexander; de Kanter, Ruben; Roch, Catherine; Gatfield, John; Boss, Christoph; von Raumer, Markus; Schindelholz, Benno; Muehlan, Clemens; van Gerven, Joop; Jenck, Francois.
Afiliação
  • Treiber A; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • de Kanter R; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • Roch C; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • Gatfield J; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • Boss C; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • von Raumer M; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • Schindelholz B; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • Muehlan C; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • van Gerven J; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
  • Jenck F; Departments of Preclinical Drug Metabolism and Pharmacokinetics (A.T., R.d.K.), Preclinical Pharmacology (C.R., F.J.), Biology (J.G.), Chemistry (C.B.), Clinical Pharmacology (C.M.), and Preclinical Development (M.v.R., B.S.), Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland; Center for Human Dru
J Pharmacol Exp Ther ; 362(3): 489-503, 2017 09.
Article em En | MEDLINE | ID: mdl-28663311
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Encéfalo / Descoberta de Drogas / Antagonistas dos Receptores de Orexina / Imidazóis Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Encéfalo / Descoberta de Drogas / Antagonistas dos Receptores de Orexina / Imidazóis Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos