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Design Optimization for Accurate Flow Simulations in 3D Printed Vascular Phantoms Derived from Computed Tomography Angiography.
Sommer, Kelsey; Izzo, Richard L; Shepard, Lauren; Podgorsak, Alexander R; Rudin, Stephen; Siddiqui, Adnan H; Wilson, Michael F; Angel, Erin; Said, Zaid; Springer, Michael; Ionita, Ciprian N.
Afiliação
  • Sommer K; Department of Biomedical Engineering, University at Buffalo, Buffalo NY 14228.
  • Izzo RL; Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo NY 14208.
  • Shepard L; Department of Biomedical Engineering, University at Buffalo, Buffalo NY 14228.
  • Podgorsak AR; Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo NY 14208.
  • Rudin S; The Jacobs Institute, Buffalo NY 14208.
  • Siddiqui AH; Department of Biomedical Engineering, University at Buffalo, Buffalo NY 14228.
  • Wilson MF; Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo NY 14208.
  • Angel E; Department of Biomedical Engineering, University at Buffalo, Buffalo NY 14228.
  • Said Z; Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo NY 14208.
  • Springer M; Department of Biomedical Engineering, University at Buffalo, Buffalo NY 14228.
  • Ionita CN; Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo NY 14208.
Proc SPIE Int Soc Opt Eng ; 101382017 Feb 11.
Article em En | MEDLINE | ID: mdl-28663663
3D printing has been used to create complex arterial phantoms to advance device testing and physiological condition evaluation. Stereolithographic (STL) files of patient-specific cardiovascular anatomy are acquired to build cardiac vasculature through advanced mesh-manipulation techniques. Management of distal branches in the arterial tree is important to make such phantoms practicable. We investigated methods to manage the distal arterial flow resistance and pressure thus creating physiologically and geometrically accurate phantoms that can be used for simulations of image-guided interventional procedures with new devices. Patient specific CT data were imported into a Vital Imaging workstation, segmented, and exported as STL files. Using a mesh-manipulation program (Meshmixer) we created flow models of the coronary tree. Distal arteries were connected to a compliance chamber. The phantom was then printed using a Stratasys Connex3 multimaterial printer: the vessel in TangoPlus and the fluid flow simulation chamber in Vero. The model was connected to a programmable pump and pressure sensors measured flow characteristics through the phantoms. Physiological flow simulations for patient-specific vasculature were done for six cardiac models (three different vasculatures comparing two new designs). For the coronary phantom we obtained physiologically relevant waves which oscillated between 80 and 120 mmHg and a flow rate of ~125 ml/min, within the literature reported values. The pressure wave was similar with those acquired in human patients. Thus we demonstrated that 3D printed phantoms can be used not only to reproduce the correct patient anatomy for device testing in image-guided interventions, but also for physiological simulations. This has great potential to advance treatment assessment and diagnosis.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc SPIE Int Soc Opt Eng Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc SPIE Int Soc Opt Eng Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos