Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers.
Redox Biol
; 13: 386-392, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28667907
ABSTRACT
Nonalcoholic fatty liver diseases (NAFLD) is one of the most common chronic liver disease in Western countries. Oxygen is a central component of the cellular microenvironment, which participate in the regulation of cell survival, differentiation, functions and energy metabolism. Accordingly, sufficient oxygen supply is an important factor for tissue durability, mainly in highly metabolic tissues, such as the liver. Accumulating evidence from the past few decades provides strong support for the existence of interruptions in oxygen availability in fatty livers. This outcome may be the consequence of both, impaired systemic microcirculation and cellular membrane modifications which occur under steatotic conditions. This review summarizes current knowledge regarding the main factors which can affect oxygen supply in fatty liver.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Apneia Obstrutiva do Sono
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Hepatopatia Gordurosa não Alcoólica
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Fígado
Limite:
Animals
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Humans
Idioma:
En
Revista:
Redox Biol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Israel