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Effect of canine mesenchymal stromal cells loaded with paclitaxel on growth of canine glioma and human glioblastoma cell lines.
Bonomi, A; Ghezzi, E; Pascucci, L; Aralla, M; Ceserani, V; Pettinari, L; Coccè, V; Guercio, A; Alessandri, G; Parati, E; Brini, A T; Zeira, O; Pessina, A.
Afiliação
  • Bonomi A; Department of Biomedical, Surgical and Dental Sciences, University of Milan, via Pascal 36, 20133 Milan, Italy.
  • Ghezzi E; Veterinary Hospital San Michele, via I Maggio 37, 26838 Tavazzano con Villavesco, Lodi, Italy.
  • Pascucci L; Department of Veterinary Medicine, University of Perugia, via San Costanzo 4, 06126 Perugia, Italy.
  • Aralla M; Veterinary Hospital San Michele, via I Maggio 37, 26838 Tavazzano con Villavesco, Lodi, Italy.
  • Ceserani V; Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, IRCCS Neurological Institute C. Besta, via Celoria 11, 20133 Milan, Italy.
  • Pettinari L; Veterinary Hospital San Michele, via I Maggio 37, 26838 Tavazzano con Villavesco, Lodi, Italy.
  • Coccè V; Department of Biomedical, Surgical and Dental Sciences, University of Milan, via Pascal 36, 20133 Milan, Italy.
  • Guercio A; Area Diagnostica Virologica dell'Istituto Zooprofilattico Sperimentale della Sicilia 'A Mirri', Palermo, Italy.
  • Alessandri G; Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, IRCCS Neurological Institute C. Besta, via Celoria 11, 20133 Milan, Italy.
  • Parati E; Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, IRCCS Neurological Institute C. Besta, via Celoria 11, 20133 Milan, Italy.
  • Brini AT; Department of Biomedical, Surgical and Dental Sciences, University of Milan, via Pascal 36, 20133 Milan, Italy; IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
  • Zeira O; Veterinary Hospital San Michele, via I Maggio 37, 26838 Tavazzano con Villavesco, Lodi, Italy.
  • Pessina A; Department of Biomedical, Surgical and Dental Sciences, University of Milan, via Pascal 36, 20133 Milan, Italy. Electronic address: augusto.pessina@unimi.it.
Vet J ; 223: 41-47, 2017 May.
Article em En | MEDLINE | ID: mdl-28671070
ABSTRACT
This study investigated whether canine mesenchymal stromal cells (cMSCs) are able to take up and release paclitaxel (PTX) in active form, and therefore whether they have potential as a tool for therapeutic delivery of this drug. cMSCs from bone marrow and adipose tissue were isolated, expanded and characterised phenotypically. cMSCs were loaded with PTX (cMSCs-PTX) and their capacity for release of PTX was determined by their effect on proliferation of cancer cells. cMSCs-PTX derived from bone marrow and adipose tissue were able to take up and then release active PTX. cMSCs-PTC inhibited proliferation of the canine glioma cell line J3T, and the human glioblastoma cell lines T98G and U87MG. The potential of canine cMSCs-PTX for treatment of canine gliomas should be investigated further.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paclitaxel / Glioblastoma / Células-Tronco Mesenquimais / Glioma / Antineoplásicos Fitogênicos Limite: Animals / Humans Idioma: En Revista: Vet J Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paclitaxel / Glioblastoma / Células-Tronco Mesenquimais / Glioma / Antineoplásicos Fitogênicos Limite: Animals / Humans Idioma: En Revista: Vet J Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália