Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB<sub>1</sub> receptor-mediated discriminative stimulus in mice.

Owens, Robert A; Mustafa, Mohammed A; Ignatowska-Jankowska, Bogna M; Damaj, M Imad; Beardsley, Patrick M; Wiley, Jenny L; Niphakis, Micah J; Cravatt, Benjamin F; Lichtman, Aron H

Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB₁ receptor-mediated discriminative stimulus in mice.

Owens, Robert A; Mustafa, Mohammed A; Ignatowska-Jankowska, Bogna M; Damaj, M Imad; Beardsley, Patrick M; Wiley, Jenny L; Niphakis, Micah J; Cravatt, Benjamin F; Lichtman, Aron H.

Afiliação

Owens RA; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Mustafa MA; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Ignatowska-Jankowska BM; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Damaj MI; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Beardsley PM; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Wiley JL; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC, 27709-2194, USA.
Niphakis MJ; The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Cravatt BF; The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Lichtman AH; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: aron.lichtman@vcuhealth.org.

Neuropharmacology ; 125: 80-86, 2017 Oct.

Article em En | MEDLINE | ID: mdl-28673548

Assuntos

Carbamatos/farmacologia; Discriminação Psicológica/efeitos dos fármacos; Inibidores Enzimáticos/farmacologia; Monoacilglicerol Lipases/antagonistas & inibidores; Receptor CB1 de Canabinoide/metabolismo; Succinimidas/farmacologia; Acetamidas/farmacologia; Amidoidrolases/antagonistas & inibidores; Amidoidrolases/metabolismo; Animais; Benzodioxóis/farmacologia; Moduladores de Receptores de Canabinoides/farmacologia; Cicloexanóis/farmacologia; Ciclo-Oxigenase 2/metabolismo; Discriminação Psicológica/fisiologia; Relação Dose-Resposta a Droga; Dronabinol/farmacologia; Masculino; Camundongos Endogâmicos C57BL; Monoacilglicerol Lipases/metabolismo; Piperidinas/farmacologia; Pirazóis/farmacologia; Rimonabanto

Palavras-chave

2-Arachidonoylglycerol (2-AG); Alpha/beta-hydrolase domain 6 (ABHD6); CP55,940 (PubChem CID: 104895); Cannabinoid-1 (CB1) receptor; Diazepam (PubChem CID: 3016); Discriminative stimulus; Drug discrimination; Endogenous cannabinoids; Fatty acid amide hydrolase (FAAH); JZL184 (PubChem CID: 25021165); KT182 (PubChem CID: 53364491); MJN110 (PubChem CID: 71722059); Monoacylglycerol lipase (MAGL); N-arachidonoylethanolamine (anandamide, AEA); Nicotine (PubChem CID: 24278591); PF-3845 (PubChem CID: 25154867); Rimonabant (PubChem CID: 104850); SA-57 (PubChem CID: 44589122); Valdecoxib (PubChem CID: 119607)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinimidas / Carbamatos / Receptor CB1 de Canabinoide / Discriminação Psicológica / Inibidores Enzimáticos / Monoacilglicerol Lipases Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neuropharmacology Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

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