Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis.

Han, Qi; Deng, Youcai; Chen, Sha; Chen, Rui; Yang, Mingzhen; Zhang, Zhujun; Sun, Xiongshan; Wang, Wei; He, Ying; Wang, Fangjie; Pan, Xiaodong; Li, Peng; Lai, Wenjing; Luo, Hongqin; Huang, Pei; Guan, Xiao; Deng, Yafei; Yan, Jun; Xu, Xianjie; Wen, Yan; Chen, An; Hu, Chuanmin; Li, Xiaohui; Li, Shuhui

Han, Qi; Deng, Youcai; Chen, Sha; Chen, Rui; Yang, Mingzhen; Zhang, Zhujun; Sun, Xiongshan; Wang, Wei; He, Ying; Wang, Fangjie; Pan, Xiaodong; Li, Peng; Lai, Wenjing; Luo, Hongqin; Huang, Pei; Guan, Xiao; Deng, Yafei; Yan, Jun; Xu, Xianjie; Wen, Yan; Chen, An; Hu, Chuanmin; Li, Xiaohui; Li, Shuhui.

Afiliação

Han Q; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Deng Y; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Chen S; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Chen R; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Yang M; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Zhang Z; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Sun X; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Wang W; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
He Y; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Wang F; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Pan X; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Li P; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Lai W; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Luo H; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Huang P; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Guan X; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Deng Y; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Yan J; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Xu X; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Wen Y; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Chen A; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Hu C; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Li X; Department of Clinical Biochemistry, Faculty of Medical Laboratory Science, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Li S; Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China. lpsh008@aliyun.com.

Sci Rep ; 7(1): 4759, 2017 07 06.

Article em En | MEDLINE | ID: mdl-28684853

Assuntos

Proteína 5 Relacionada à Autofagia/genética; Autofagia/genética; Neoplasias da Mama/genética; Carcinogênese/genética; Regulação Neoplásica da Expressão Gênica; Proteína 2 de Membrana Associada ao Lisossomo/genética; Animais; Proteína 5 Relacionada à Autofagia/metabolismo; Neoplasias da Mama/metabolismo; Neoplasias da Mama/mortalidade; Neoplasias da Mama/patologia; Carcinogênese/metabolismo; Carcinogênese/patologia; Linhagem Celular Tumoral; Feminino; Humanos; Metástase Linfática; Proteína 2 de Membrana Associada ao Lisossomo/antagonistas & inibidores; Proteína 2 de Membrana Associada ao Lisossomo/metabolismo; Lisossomos/metabolismo; Camundongos Endogâmicos BALB C; Camundongos Nus; Gradação de Tumores; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Transdução de Sinais; Análise de Sobrevida; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Proteína 2 de Membrana Associada ao Lisossomo / Carcinogênese / Proteína 5 Relacionada à Autofagia Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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