Patient-specific biomechanical model of hypoplastic left heart to predict post-operative cardio-circulatory behaviour.
Med Eng Phys
; 47: 85-92, 2017 09.
Article
em En
| MEDLINE
| ID: mdl-28698113
ABSTRACT
Hypoplastic left heart syndrome is a complex congenital heart disease characterised by the underdevelopment of the left ventricle normally treated with a three-stage surgical repair. In this study, a multiscale closed-loop cardio-circulatory model is created to reproduce the pre-operative condition of a patient suffering from such pathology and virtual surgery is performed. Firstly, cardio-circulatory parameters are estimated using a fully closed-loop cardio-circulatory lumped parameter model. Secondly, a 3D standalone FEA model is build up to obtain active and passive ventricular characteristics and unloaded reference state. Lastly, the 3D model of the single ventricle is coupled to the lumped parameter model of the circulation obtaining a multiscale closed-loop pre-operative model. Lacking any information on the fibre orientation, two cases were simulated (i) fibre distributed as in the physiological right ventricle and (ii) fibre as in the physiological left ventricle. Once the pre-operative condition is satisfactorily simulated for the two cases, virtual surgery is performed. The post-operative results in the two cases highlighted similar hemodynamic behaviour but different local mechanics. This finding suggests that the knowledge of the patient-specific fibre arrangement is important to correctly estimate the single ventricle's working condition and consequently can be valuable to support clinical decision.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disfunção Ventricular
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Síndrome do Coração Esquerdo Hipoplásico
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Cirurgia Assistida por Computador
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Modelagem Computacional Específica para o Paciente
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Ventrículos do Coração
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Modelos Cardiovasculares
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
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Infant
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Newborn
Idioma:
En
Revista:
Med Eng Phys
Assunto da revista:
BIOFISICA
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ENGENHARIA BIOMEDICA
Ano de publicação:
2017
Tipo de documento:
Article