Emergence of the Asian genotype of DENV-1 in South India.
Virology
; 510: 40-45, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28704695
ABSTRACT
A large outbreak of dengue occurred in Tamil Nadu, South India in 2012 with 12,000 cases and CFR of 0.5%. Molecular characterization of virus present in the sera of dengue patients was undertaken to determine if there were changes in the virus population. All four serotypes were circulating but DENV-1 was dominant, present in 52% of the serotyped samples. Furthermore, the genotype of only DENV-1 had changed; the Asian genotype had displaced the American/African. Phylogenetic analysis revealed that the Asian genotype was introduced from Singapore and shared 99% similarity with viruses, associated with large outbreaks in Singapore and Sri Lanka. We report for the first time the emergence of the Asian genotype of DENV-1 in southern India causing an extensive and severe outbreak. The study proves how movement of DENV can affect dengue outbreaks and underscores the need for close molecular monitoring of DENV.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
/
Dengue
/
Vírus da Dengue
/
Genótipo
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Virology
Ano de publicação:
2017
Tipo de documento:
Article