Topographical projections from the nucleus basalis magnocellularis (Meynert) to the frontal cortex: A voltage-sensitive dye imaging study in rats.
Brain Stimul
; 10(5): 977-980, 2017.
Article
em En
| MEDLINE
| ID: mdl-28709847
ABSTRACT
BACKGROUND:
The nucleus basalis magnocellularis/Meynert (NBM) has been explored as a new target for deep brain stimulation for neurological disorders. Although anatomical studies suggest the existence of cholinergic topographical projections of the NBM, it is still unknown whether NBM subregions differentially activate the frontal cortex.OBJECTIVE:
To investigate the topography between the NBM and frontal cortex.METHODS:
Electrical stimulation was applied to the anterior and posterior sites of the NBM in rats, and the evoked frontal activity was investigated using voltage-sensitive dye (VSD) imaging.RESULTS:
VSD imaging revealed the functional topography of the NBM and frontal cortex the anteroposterior axis of the NBM corresponded to the mediolateral axis of the dorsal frontal cortex.CONCLUSION:
The present results suggest site-specific control of frontal neuronal activity by the NBM. These findings have practical implications, as the anterior and posterior parts of the NBM could be targeted to improve cognitive and motor function, respectively.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleo Basal de Meynert
/
Imagens com Corantes Sensíveis à Voltagem
/
Lobo Frontal
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Brain Stimul
Assunto da revista:
CEREBRO
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Japão