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Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin.
Price, Daniel J; Khuphe, Mthulisi; Davies, Robert P W; McLaughlan, James R; Ingram, Nicola; Thornton, Paul D.
Afiliação
  • Price DJ; School of Chemistry, University of Leeds, LS2 9JT, UK. p.d.thornton@leeds.ac.uk.
  • Khuphe M; School of Chemistry, University of Leeds, LS2 9JT, UK. p.d.thornton@leeds.ac.uk.
  • Davies RPW; Oral Biology (School of Dentistry), University of Leeds, LS2 9JT, UK.
  • McLaughlan JR; School of Electronic & Electrical Engineering, University of Leeds, LS2 9JT, UK.
  • Ingram N; School of Chemistry, University of Leeds, LS2 9JT, UK. p.d.thornton@leeds.ac.uk and Leeds Institute of Biomedical and Clinical Sciences, Wellcome Trust Brenner Building, St James's University Hospital, Leeds, LS9 7TF, UK.
  • Thornton PD; School of Chemistry, University of Leeds, LS2 9JT, UK. p.d.thornton@leeds.ac.uk.
Chem Commun (Camb) ; 53(62): 8687-8690, 2017 Aug 11.
Article em En | MEDLINE | ID: mdl-28722060
Biodegradable polymers have emerged as highly effective drug delivery vehicles. We combine N-carboxyanhydride and O-carboxyanhydride ring opening polymerisations to synthesise a poly(amino acid)-polyester graft copolymer capable of encapsulating, and subsequently releasing doxorubicin via acid-mediated hydrolysis. Consequently, the nanoparticles detailed are extremely promising vehicles for the controlled delivery of chemotherapeutic agents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Poliésteres / Portadores de Fármacos / Doxorrubicina / Nanopartículas Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Poliésteres / Portadores de Fármacos / Doxorrubicina / Nanopartículas Limite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido