UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.

Nakashima, Ryota; Goto, Yoko; Koyasu, Sho; Kobayashi, Minoru; Morinibu, Akiyo; Yoshimura, Michio; Hiraoka, Masahiro; Hammond, Ester M; Harada, Hiroshi

Nakashima, Ryota; Goto, Yoko; Koyasu, Sho; Kobayashi, Minoru; Morinibu, Akiyo; Yoshimura, Michio; Hiraoka, Masahiro; Hammond, Ester M; Harada, Hiroshi.

Afiliação

Nakashima R; Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Goto Y; Laboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation Biology Center, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Koyasu S; Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. ygoto@kuhp.kyoto-u.ac.jp.
Kobayashi M; Laboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation Biology Center, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Morinibu A; Laboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation Biology Center, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Yoshimura M; Laboratory of Cancer Cell Biology, Department of Genome Dynamics, Radiation Biology Center, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Hiraoka M; Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Hammond EM; Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Harada H; CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, United Kingdom.

Sci Rep ; 7(1): 6879, 2017 07 31.

Article em En | MEDLINE | ID: mdl-28761052

Assuntos

Neoplasias da Mama/metabolismo; Glutationa/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Tolerância a Radiação; Ubiquitina Tiolesterase/metabolismo; Animais; Neoplasias da Mama/radioterapia; Metabolismo dos Carboidratos; Feminino; Células HEK293; Células HeLa; Humanos; Camundongos; Raios X

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolerância a Radiação / Neoplasias da Mama / Ubiquitina Tiolesterase / Subunidade alfa do Fator 1 Induzível por Hipóxia / Glutationa Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google