Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study.
Neuropsychiatr Dis Treat
; 13: 1895-1903, 2017.
Article
em En
| MEDLINE
| ID: mdl-28765711
ABSTRACT
BACKGROUND:
Multiple sclerosis (MS) is a complex autoimmune disease with a heterogeneous presentation and diverse disease course. Recent studies indicate a rising prevalence of MS in the Middle East.OBJECTIVE:
To characterize the demographics and disease features of Egyptian patients attending four tertiary referral MS centers in Cairo. MATERIALS ANDMETHODS:
This was a retrospective, observational study on 1,581 patients between 2001 and 2015. Medical records were reviewed and data were identified and extracted in a standardized electronic registry.RESULTS:
The mean age of disease onset was 26.6±7.8 years, with the majority being female (2.111). Relapsing-remitting MS was the most common type (75.1%). The main presenting symptom was motor weakness (43.9%), which was also the most frequent symptom during the disease course. Family history of MS was found in 2.28%. Higher initial Expanded Disability Status Scale score, black holes, and infratentorial lesions on initial magnetic resonance imaging were independent factors for disease progression by univariate analysis (OR 3.87 [95% CI 1.84-6.51], 4.14 [95% CI 3.08-5.58], 4.07 [95% CI 3.21-4.99], respectively); however, in multivariate analysis, only infratentorial lesions were an independent risk for disease progression (OR 6, 95% CI 2.99-12.02; P=0.0005).CONCLUSION:
The results from this registry - the largest for MS in the Arab region to date - are comparable to other registries with slight differences.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Neuropsychiatr Dis Treat
Ano de publicação:
2017
Tipo de documento:
Article