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Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells.
Shaik, Anver Basha; Rao, Garikapati Koteswara; Kumar, G Bharath; Patel, Nibeditha; Reddy, Vangala Santhosh; Khan, Irfan; Routhu, Sunitha Rani; Kumar, C Ganesh; Veena, Immadi; Chandra Shekar, Kunta; Barkume, Madan; Jadhav, Shailesh; Juvekar, Aarti; Kode, Jyoti; Pal-Bhadra, Manika; Kamal, Ahmed.
Afiliação
  • Shaik AB; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Rao GK; Centre for Chemical Biology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Kumar GB; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Patel N; Centre for Chemical Biology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Reddy VS; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Khan I; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Routhu SR; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Kumar CG; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Veena I; Centre for Chemical Biology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Chandra Shekar K; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Barkume M; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India.
  • Jadhav S; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India.
  • Juvekar A; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India.
  • Kode J; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: jkode@actrec.gov.in.
  • Pal-Bhadra M; Centre for Chemical Biology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: manika@iict.res.in.
  • Kamal A; Medicinal Chemistry and Pharmacology, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: ahmedkamal@iict.res.in.
Eur J Med Chem ; 139: 305-324, 2017 Oct 20.
Article em En | MEDLINE | ID: mdl-28803046
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Neoplasias da Mama / Desenho de Fármacos / Apoptose / Chalconas / Inibidores de Proteínas Quinases / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia País de publicação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Neoplasias da Mama / Desenho de Fármacos / Apoptose / Chalconas / Inibidores de Proteínas Quinases / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Índia País de publicação: França