Your browser doesn't support javascript.
loading
Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment.
Xie, Yingqiu; Mustafa, Aidana; Yerzhan, Adina; Merzhakupova, Dalmira; Yerlan, Perizat; N Orakov, Askarbek; Wang, Xiao; Huang, Yi; Miao, Lixia.
Afiliação
  • Xie Y; Department of Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
  • Mustafa A; College of Basic Medicine, Wuhan University, Wuhan 430071, China.
  • Yerzhan A; Department of Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
  • Merzhakupova D; Department of Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
  • Yerlan P; Department of Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
  • N Orakov A; Department of Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
  • Wang X; Department of Biology, School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
  • Huang Y; Shandong Analysis and Test Center, Shandong Academy of Sciences, 19 Keyuan Street, Jinan 250014, China.
  • Miao L; Department of Urology, Shenzhen University Luohu Hospital, Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen 51800, China.
Cell Death Discov ; 3: 17036, 2017.
Article em En | MEDLINE | ID: mdl-28811933
Matrix metalloproteinase (MMP) is defined as an endopeptidase in the extracellular matrix (ECM), which plays essential roles in physiological processes such as organogenesis, wound healing, angiogenesis, apoptosis and motility. MMPs are produced and assembled in the cytoplasm as proenzymes with a cytoplasmic domain and require extracellular activation. MMPs can degrade receptors, extracellular matrix proteins, PARPs and release apoptotic substances. MMPs have been found in the cytosol, organelles and extracellular compartments and recently many types of MMPs have been found in the nucleus. However, the mechanisms and roles of MMPs inside the cell nucleus are still poorly understood. Here we summarized the nuclear localization mechanisms of MMPs and their functions in the nucleus such as apoptosis, tissue remodeling upon injury and cancer progression. Most importantly, we found that nuclear MMPs have evolved to translocate to membrane and target ECM possibly through evolution of nuclear localization signal (NLS), natural selection and anti-apoptotic survival. Thus, the knowledge about the evolution and regulation of nuclear MMPs appears to be essential in understanding a variety of cellular processes along with the development of MMP-targeted therapeutic drugs against the progression of certain diseases.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Death Discov Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Cazaquistão País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Death Discov Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Cazaquistão País de publicação: Estados Unidos