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Transition-Metal-Free Trifluoromethylation of Aldehyde Derivatives with Sodium Trifluoromethanesulfinate.
Tan, Zheng; Zhang, Shiwei; Zhang, Yan; Li, Yunpeng; Ni, Minjie; Feng, Bainian.
Afiliação
  • Tan Z; School of Pharmaceutical Science, Jiangnan University , Wuxi 214122, P. R. China.
  • Zhang S; School of Pharmaceutical Science, Jiangnan University , Wuxi 214122, P. R. China.
  • Zhang Y; School of Pharmaceutical Science, Jiangnan University , Wuxi 214122, P. R. China.
  • Li Y; School of Pharmaceutical Science, Jiangnan University , Wuxi 214122, P. R. China.
  • Ni M; School of Pharmaceutical Science, Jiangnan University , Wuxi 214122, P. R. China.
  • Feng B; School of Pharmaceutical Science, Jiangnan University , Wuxi 214122, P. R. China.
J Org Chem ; 82(18): 9384-9399, 2017 09 15.
Article em En | MEDLINE | ID: mdl-28820258
A metal-free and cost-effective synthetic protocol for the trifluoromethylation of N,N-disubstituted hydrazones with Langlois's reagent (CF3SO2Na) to afford the corresponding functionalized trifluoromethyl ketone hydrazones has been established. It is proposed that a radical/SET mechanism proceeding via a trifluoroalkyl radical may be involved in the reaction. Applications of the methodology in industry will be found and the development of new methods for trifluoromethylation with Langlois's reagent will be continued in our laboratory.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos