Anti-müllerian hormone and ovarian reserve in systemic lupus erythematosus.
Clin Rheumatol
; 36(12): 2853-2854, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28828533
ABSTRACT
Systemic lupus erythematosus (SLE) is a chronic immune-mediated inflammatory disease that affects predominantly females during childbearing age (Lateef and Petri Best Pract Res Clin Rheumatol 27(3)435-447, 2013). Fertility in SLE patients is considered to be normal (Clowse et al. Arthritis Care Res (Hoboken) 64(5)668-674, 2012; Ekblom-Kullberg et al. Scand J Rheumatol 38375-380, 2009) but several known factors may negatively influence fertility. Immune mechanisms are also thought to be an important cause of premature ovarian senescence, characterized by reduced ovarian reserve markers such as anti-Müllerian hormone (AMH) (Oktem et al. Obstet Gynecol Surv 70(3)196-210, 2015; Bermas and Sammaritano Fertil Res Pract 113, 2015; Østensen Int J Clin Rheumtol 8(1)27-37, 2013; Ulug et al. Am J Reprod Immunol 72(1)85-88, 2014; Lawrenz et al. Lupus 20(11)1193-1197, 2011). We evaluated the ovarian reserve of women in reproductive age with SLE, by measuring AMH levels and we compared it to that of non-SLE women. We also analyzed the association of SLE disease characteristics with AMH levels. AMH levels were decreased in this population of SLE women, accounting for a high proportion of women with criteria for low ovarian reserve. Age and SLE damage were associated with abnormally lower AMH levels in our SLE patients. In this way, SLE may have a negative influence on the ovarian reserve.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Antimülleriano
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Reserva Ovariana
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Lúpus Eritematoso Sistêmico
Limite:
Adolescent
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Adult
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Female
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Humans
Idioma:
En
Revista:
Clin Rheumatol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Portugal