Your browser doesn't support javascript.
loading
Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.
De La Fuente, Alerie Guzman; Lange, Simona; Silva, Maria Elena; Gonzalez, Ginez A; Tempfer, Herbert; van Wijngaarden, Peter; Zhao, Chao; Di Canio, Ludovica; Trost, Andrea; Bieler, Lara; Zaunmair, Pia; Rotheneichner, Peter; O'Sullivan, Anna; Couillard-Despres, Sebastien; Errea, Oihana; Mäe, Maarja A; Andrae, Johanna; He, Liqun; Keller, Annika; Bátiz, Luis F; Betsholtz, Christer; Aigner, Ludwig; Franklin, Robin J M; Rivera, Francisco J.
Afiliação
  • De La Fuente AG; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK.
  • Lange S; Institute of Molecular Regenerative Medicine, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Silva ME; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK; Institute of Molecular Regenerative Medicine, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medica
  • Gonzalez GA; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK.
  • Tempfer H; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Institute for Tendon and Bone Regeneration, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austri
  • van Wijngaarden P; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Ophthalmology, Department of Surgery, University of Melbourne, Australia.
  • Zhao C; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK.
  • Di Canio L; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK.
  • Trost A; Institute of Molecular Regenerative Medicine, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Ophthalmology/Optometry and Research Program for Exper
  • Bieler L; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Institute of Experimental Neuroregeneration, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Zaunmair P; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Institute of Experimental Neuroregeneration, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Rotheneichner P; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Institute of Experimental Neuroregeneration, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • O'Sullivan A; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Institute of Experimental Neuroregeneration, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Couillard-Despres S; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Institute of Experimental Neuroregeneration, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Errea O; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK.
  • Mäe MA; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • Andrae J; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
  • He L; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin 300052, China.
  • Keller A; Division of Neurosurgery, Zürich University Hospital, Zürich University, 8091 Zürich, Switzerland.
  • Bátiz LF; Laboratory of Stem Cells and Neuroregeneration, Institute of Anatomy, Histology and Pathology, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile; Centro de Investigación Biomédica (CIB), Facultad de Medicina, Universidad de los Andes, Santiago, Chile.
  • Betsholtz C; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden; Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet Novum, 141 57 Huddinge, Sweden.
  • Aigner L; Institute of Molecular Regenerative Medicine, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Aust
  • Franklin RJM; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK.
  • Rivera FJ; Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB20AH, UK; Institute of Molecular Regenerative Medicine, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medica
Cell Rep ; 20(8): 1755-1764, 2017 Aug 22.
Article em En | MEDLINE | ID: mdl-28834740
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfbret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Central / Oligodendroglia / Pericitos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Nervoso Central / Oligodendroglia / Pericitos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos