Activity of the antioxidant enzyme paraoxonase in Argentinean children living at high altitude.
Redox Rep
; 23(1): 35-40, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-28853330
ABSTRACT
BACKGROUND:
Children living at high altitude in San Antonio de los Cobres (SAC), Argentina, were shown to have lower high-density lipoprotein cholesterol (HDL-C) levels than Buenos Aires (BA) children. HDL antioxidant capacity is mainly attributed to paraoxonase1 (PON1).OBJECTIVE:
To compare PON1 activity in indigenous SAC vs. BA children.METHODS:
A cross-sectional study compared 158 SAC vs. 97 BA children (6-16 years). Anthropometric data and lipoprotein profile were measured. PON1 was evaluated employing paraoxon (PON) and phenylacetate (ARE) activity.RESULTS:
The prevalence of overweight/obesity was lower in SAC than in BA children (18.3 vs. 30.9%). Triglycerides (1.34 vs. 0.90â mmol/l), apo B (0.84 vs.0.72â g/l), apo A-I (1.33 vs. 1.27â g/l), and ARE activity (100 vs. 90â µmol/ml/min) were higher, while HDL-C (1.16 vs. 1.32â mmol/l) and PON activity (170 vs. 203â nmol/ml/min) were lower in SAC than in BA. Separate multiple linear regression analyses showed that SAC children had significantly higher triglyceride (Beta -0.38), apo B (Beta -0.34), and ARE (Beta -0.36) plus lower HDL-C (Beta 0.33) and PON (Beta 0.25) compared with BA; adjusted for age, gender, and BMI.CONCLUSION:
SAC showed an unfavorable lipoprotein profile, lower PON and higher ARE activities compared with BA children, suggesting the presence of altered HDL metabolism and antioxidant capacity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arildialquilfosfatase
/
Obesidade Infantil
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Redox Rep
Assunto da revista:
BIOQUIMICA
/
METABOLISMO
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Argentina