Development of polyurethanes for bone repair.
Mater Sci Eng C Mater Biol Appl
; 80: 736-747, 2017 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-28866223
ABSTRACT
The purpose of this paper is to review recent developments on polyurethanes aimed at the design, synthesis, modifications, and biological properties in the field of bone tissue engineering. Different polyurethane systems are presented and discussed in terms of biodegradation, biocompatibility and bioactivity. A comprehensive discussion is provided of the influence of hard to soft segments ratio, catalysts, stiffness and hydrophilicity of polyurethanes. Interaction with various cells, behavior in vivo and current strategies in enhancing bioactivity of polyurethanes are described. The discussion on the incorporation of biomolecules and growth factors, surface modifications, and obtaining polyurethane-ceramics composites strategies is held. The main emphasis is placed on the progress of polyurethane applications in bone regeneration, including bone void fillers, shape memory scaffolds, and drug carrier.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliuretanos
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Polônia