Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity.
Arch Pharm Res
; 41(12): 1117-1130, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-28895057
ABSTRACT
Four new ursane-type triterpenoid saponins, clinopoursaponins A-D (1-4), six new oleanane-type triterpenoid saponins, clinopodiside VII-XII (5-10), as well as eight known triterpene analogues (11-18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D (1H and 13C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1-18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1. Compounds 8, 9 and 18 exhibited significant protective effects, while compound 1 exhibited cytotoxic activity with IC50 value of 7.4 µm compared to 7.6 µm for the positive control 10-hydroxycamptothecin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Triterpenos
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Lamiaceae
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Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2018
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
/
CORÉIA DO SUL
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KR
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SOUTH KOREA