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Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity.
Zhu, Yin-Di; Hong, Jing-Yi; Bao, Feng-Da; Xing, Na; Wang, Ling-Tian; Sun, Zhong-Hao; Luo, Yun; Jiang, Hai; Xu, Xu-Dong; Zhu, Nai-Liang; Wu, Hai-Feng; Sun, Gui-Bo; Yang, Jun-Shan.
Afiliação
  • Zhu YD; School of Pharmacy, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.
  • Hong JY; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China.
  • Bao FD; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China.
  • Xing N; School of Pharmacy, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.
  • Wang LT; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China.
  • Sun ZH; Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, 150040, People's Republic of China.
  • Luo Y; School of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
  • Jiang H; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China.
  • Xu XD; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China.
  • Zhu NL; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China.
  • Wu HF; Key Laboratory of Chinese Materia Medica, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, 150040, People's Republic of China.
  • Sun GB; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China. xdxu@implad.ac.cn.
  • Yang JS; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, People's Republic of China. nlzhu@implad.ac.cn.
Arch Pharm Res ; 41(12): 1117-1130, 2018 Dec.
Article em En | MEDLINE | ID: mdl-28895057
ABSTRACT
Four new ursane-type triterpenoid saponins, clinopoursaponins A-D (1-4), six new oleanane-type triterpenoid saponins, clinopodiside VII-XII (5-10), as well as eight known triterpene analogues (11-18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D (1H and 13C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1-18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1. Compounds 8, 9 and 18 exhibited significant protective effects, while compound 1 exhibited cytotoxic activity with IC50 value of 7.4 µm compared to 7.6 µm for the positive control 10-hydroxycamptothecin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Triterpenos / Lamiaceae / Antineoplásicos Limite: Animals Idioma: En Revista: Arch Pharm Res Ano de publicação: 2018 Tipo de documento: Article País de publicação: COREA DEL SUR / CORÉIA DO SUL / KR / SOUTH KOREA
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saponinas / Triterpenos / Lamiaceae / Antineoplásicos Limite: Animals Idioma: En Revista: Arch Pharm Res Ano de publicação: 2018 Tipo de documento: Article País de publicação: COREA DEL SUR / CORÉIA DO SUL / KR / SOUTH KOREA