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Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine.
van Ditzhuijzen, Nienke S; Kurata, Mie; van den Heuvel, Mieke; Sorop, Oana; van Duin, Richard W B; Krabbendam-Peters, Ilona; Ligthart, Jurgen; Witberg, Karen; Murawska, Magdalena; Bouma, Brett; Villiger, Martin; Garcia-Garcia, Hector M; Serruys, Patrick W; Zijlstra, Felix; van Soest, Gijs; Duncker, Dirk-Jan; Regar, Evelyn; van Beusekom, Heleen M M.
Afiliação
  • van Ditzhuijzen NS; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Kurata M; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • van den Heuvel M; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Sorop O; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • van Duin RWB; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Krabbendam-Peters I; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Ligthart J; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Witberg K; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Murawska M; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Bouma B; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Villiger M; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Garcia-Garcia HM; Cardialysis B.V., Rotterdam, The Netherlands.
  • Serruys PW; Cardialysis B.V., Rotterdam, The Netherlands.
  • Zijlstra F; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • van Soest G; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Duncker DJ; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Regar E; Department of Cardiology, Thoraxcenter, Cardiovascular Research school COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • van Beusekom HMM; Dept. of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland.
PLoS One ; 12(9): e0183419, 2017.
Article em En | MEDLINE | ID: mdl-28898243
BACKGROUND: DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS. AIM: The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a 'fast-food' diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography (OCT)-imaging and histology. METHODS: Fifteen male swine were evaluated. Eight received streptozotocin-injection to induce DM. After 9 months (M), 32 single BVS were implanted in epicardial arteries with a stent to artery (S/A)-ratio of 1.1:1 under quantitative coronary angiography (QCA) and OCT guidance. Lumen, scaffold, neointimal coverage and composition were assessed by QCA, OCT and near-infrared spectroscopy (NIRS) pre- and/or post-procedure, at 3M and 6M. Additionally, polarization-sensitive (PS)-OCT was performed in 7 swine at 6M. After sacrifice at 3M and 6M, histology and polymer degradation analysis were performed. RESULTS: Late lumen loss was high (~60%) within the first 3M after BVS-implantation (P<0.01 FF-DM vs. FF-NDM) and stabilized between 3M and 6M (<5% change in FF-DM, ~10% in FF-NDM; P>0.20). Neointimal coverage was highly heterogeneous in all swine (DM vs. NDM P>0.05), with focal lipid accumulation, irregular collagen distribution and neointimal calcification. Likewise, polymer mass loss was low (~2% at 3M, ~5% at 6M;P>0.20) and not associated with DM or inflammation. CONCLUSION: Scaffold coverage showed signs of neo-atherosclerosis in all FF-DM and FF-NDM swine, scaffold polymer was preserved and the vascular response to BVS was not influenced by diabetes.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Implantes Absorvíveis / Diabetes Mellitus / Aterosclerose / Alicerces Teciduais / Neointima Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Implantes Absorvíveis / Diabetes Mellitus / Aterosclerose / Alicerces Teciduais / Neointima Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos