Investigation of Vitamin D Receptor Gene Polymorphism in Pediatric Patients with Brain Cancer.
Indian J Med Paediatr Oncol
; 38(2): 128-132, 2017.
Article
em En
| MEDLINE
| ID: mdl-28900319
ABSTRACT
AIM:
In recent years, it is believed that Vitamin D may play a protective role in some cancer types. Certain regions of the Vitamin D receptor (VDR) gene may show a genetic difference in structure. The most frequent polymorphisms in this gene are in Taq-1, Fok-1, and Bsm-1 regions. Some adult cancer types are associated with VDR gene polymorphism such as; colorectal carcinoma, breast carcinoma, and prostate carcinoma. Reviewing the medical literature, no such study had been done on children so far. MATERIALS ANDMETHODS:
We investigated the association of the three most common gene polymorphisms (Taq-1, Fok-1, and Bsm-1 regions) in VDR gene in 32 children with brain tumors and forty control healthy volunteers.RESULTS:
We could not find any relationship between childhood brain tumors and VDR gene polymorphism in these three regions.CONCLUSION:
The present results suggest that the Taq-1, Fok-1, and Bsm-1 polymorphism in the VDR gene and pediatric brain cancers have no association.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Indian J Med Paediatr Oncol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Turquia