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CRISPR correction of the PRKAG2 gene mutation in the patient's induced pluripotent stem cell-derived cardiomyocytes eliminates electrophysiological and structural abnormalities.
Ben Jehuda, Ronen; Eisen, Binyamin; Shemer, Yuval; Mekies, Lucy N; Szantai, Agnes; Reiter, Irina; Cui, Huanhuan; Guan, Kaomei; Haron-Khun, Shiraz; Freimark, Dov; Sperling, Silke R; Gherghiceanu, Mihaela; Arad, Michael; Binah, Ofer.
Afiliação
  • Ben Jehuda R; Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel; The Rappaport Institute, Technion, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel; Department of Biotechnology, Technion, Haifa, Israel.
  • Eisen B; Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel; The Rappaport Institute, Technion, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Shemer Y; Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel; The Rappaport Institute, Technion, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Mekies LN; Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel; The Rappaport Institute, Technion, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Szantai A; Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel; The Rappaport Institute, Technion, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel; Department of Biochemistry, University of Szeged, Szeged, Hungary.
  • Reiter I; Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel; The Rappaport Institute, Technion, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel.
  • Cui H; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Guan K; DZHK-German Centre for Cardiovascular Research, Berlin, Germany; Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.
  • Haron-Khun S; Leviev Heart Center, Sheba Medical Center, and Tel Aviv University, Tel Aviv, Israel.
  • Freimark D; Leviev Heart Center, Sheba Medical Center, and Tel Aviv University, Tel Aviv, Israel.
  • Sperling SR; Department of Cardiovascular Genetics, Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany; DZHK-German Centre for Cardiovascular Research, Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany.
  • Gherghiceanu M; "Victor Babes" National Institute of Pathology, Bucharest, Romania.
  • Arad M; Leviev Heart Center, Sheba Medical Center, and Tel Aviv University, Tel Aviv, Israel.
  • Binah O; Department of Physiology, Biophysics and Systems Biology, Technion, Haifa, Israel; The Rappaport Institute, Technion, Haifa, Israel; Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address: binah@tx.technion.ac.il.
Heart Rhythm ; 15(2): 267-276, 2018 02.
Article em En | MEDLINE | ID: mdl-28917552
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Wolff-Parkinson-White / DNA / Miócitos Cardíacos / Proteínas Quinases Ativadas por AMP / Células-Tronco Pluripotentes Induzidas / Mutação Limite: Humans / Male / Middle aged Idioma: En Revista: Heart Rhythm Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Israel País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Wolff-Parkinson-White / DNA / Miócitos Cardíacos / Proteínas Quinases Ativadas por AMP / Células-Tronco Pluripotentes Induzidas / Mutação Limite: Humans / Male / Middle aged Idioma: En Revista: Heart Rhythm Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Israel País de publicação: Estados Unidos