Single-dose pharmacokinetics and bioavailability of famotidine in man. Results of multicenter collaborative studies.
Biopharm Drug Dispos
; 8(6): 549-60, 1987.
Article
em En
| MEDLINE
| ID: mdl-2892544
ABSTRACT
Pharmacokinetics and bioavailability of famotidine, a new H2-receptor antagonist, were investigated in healthy subjects in five clinical studies. Linear pharmacokinetics were observed following either intravenous or oral administration. Plasma clearance averaged 463 ml min-1. Renal clearance averaged 310 ml min-1, which exceeded the glomerular filtration rate. Renal excretion was the major route of elimination. Urinary recovery of unchanged drug following intravenous administration was about 67 per cent. Famotidine plasma half-life was approximately 2.6 h. Oral absorption was incomplete. The bioavailability averaged 43 per cent of the dose.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Antagonistas dos Receptores H2 da Histamina
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biopharm Drug Dispos
Ano de publicação:
1987
Tipo de documento:
Article