Derivatives of Bst-like Gss-polymerase with improved processivity and inhibitor tolerance.

Oscorbin, Igor P; Belousova, Ekaterina A; Boyarskikh, Ulyana A; Zakabunin, Aleksandr I; Khrapov, Evgeny A; Filipenko, Maksim L

Oscorbin, Igor P; Belousova, Ekaterina A; Boyarskikh, Ulyana A; Zakabunin, Aleksandr I; Khrapov, Evgeny A; Filipenko, Maksim L.

Afiliação

Oscorbin IP; Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 8, Novosibirsk 630090, Russian Federation.
Belousova EA; Laboratory of genomic technologies, Novosibirsk State University, Pirogova street 2, Novosibirsk 630090, Russian Federation.
Boyarskikh UA; Laboratory of Bioorganic chemistry of enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 8, Novosibirsk 630090, Russian Federation.
Zakabunin AI; Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 8, Novosibirsk 630090, Russian Federation.
Khrapov EA; Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 8, Novosibirsk 630090, Russian Federation.
Filipenko ML; Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 8, Novosibirsk 630090, Russian Federation.

Nucleic Acids Res ; 45(16): 9595-9610, 2017 Sep 19.

Article em En | MEDLINE | ID: mdl-28934494

Assuntos

DNA Polimerase I/metabolismo; Geobacillus/enzimologia; Engenharia de Proteínas/métodos; Proteínas Recombinantes de Fusão/genética; Domínio Catalítico; Clonagem Molecular; DNA/metabolismo; DNA Polimerase I/antagonistas & inibidores; DNA Polimerase I/genética; Inibidores Enzimáticos/farmacologia; Genoma Humano; Geobacillus/genética; Geobacillus stearothermophilus/enzimologia; Geobacillus stearothermophilus/genética; Humanos; Técnicas de Amplificação de Ácido Nucleico/métodos; Estabilidade Proteica; Pyrococcus abyssi/genética; Proteínas Recombinantes de Fusão/metabolismo; Sulfolobus/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Engenharia de Proteínas / DNA Polimerase I / Geobacillus Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido

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