Macrophage ubiquitin-specific protease 2 modifies insulin sensitivity in obese mice.

Saito, Natsuko; Kimura, Shunsuke; Miyamoto, Tomomi; Fukushima, Sanae; Amagasa, Misato; Shimamoto, Yoshinori; Nishioka, Chieko; Okamoto, Shiki; Toda, Chitoku; Washio, Kohei; Asano, Atsushi; Miyoshi, Ichiro; Takahashi, Eiki; Kitamura, Hiroshi

Saito, Natsuko; Kimura, Shunsuke; Miyamoto, Tomomi; Fukushima, Sanae; Amagasa, Misato; Shimamoto, Yoshinori; Nishioka, Chieko; Okamoto, Shiki; Toda, Chitoku; Washio, Kohei; Asano, Atsushi; Miyoshi, Ichiro; Takahashi, Eiki; Kitamura, Hiroshi.

Afiliação

Saito N; Laboratory of Veterinary Physiology, Department of Veterinary Medicine, and Laboratory of Animal Therapeutics, Japan.
Kimura S; Laboratory of Histology and Cytology, Department of Functional Morphology, Graduate School of Medical Sciences, Hokkaido University, Kita15, Nishi7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan.
Miyamoto T; Department of Comparative and Experimental Medicine, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
Fukushima S; Research Resources Center, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Amagasa M; Laboratory of Veterinary Physiology, Department of Veterinary Medicine, and Laboratory of Animal Therapeutics, Japan.
Shimamoto Y; Department of Veterinary Science, Rakuno Gakuen University, 582 Midorimachi, Bunkyodai, Ebetsu, Hokkaido 069-8501, Japan.
Nishioka C; Research Resources Center, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Okamoto S; Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, 38 Nishigonaka Myodaiji, Okazaki, Aichi 444-8585, Japan.
Toda C; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA.
Washio K; Laboratory of Veterinary Physiology, Department of Veterinary Medicine, and Laboratory of Animal Therapeutics, Japan.
Asano A; Laboratory of Laboratory Animal, Department of Basic Veterinary Science, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
Miyoshi I; Department of Comparative and Experimental Medicine, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
Takahashi E; Research Resources Center, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Kitamura H; Laboratory of Veterinary Physiology, Department of Veterinary Medicine, and Laboratory of Animal Therapeutics, Japan.

Biochem Biophys Rep ; 9: 322-329, 2017 Mar.

Article em En | MEDLINE | ID: mdl-28956020

Palavras-chave

DMEM, Dulbecco's modified Eagle medium; Diabetes; ELISA, enzyme-linked immunosorbent assay; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HFD, high-fat diet; HOMA-IR, homeostatic model assessment as an index of insulin resistance; IL, interleukin; IR, insulin receptor; IRS, insulin receptor substrate; Insulin; KD, knock down; KO, knockout; Macrophage; NCD, normal chow diet; NEFA, nonesterified fatty acid; Obesity; PDK, phosphoinositide-dependent kinase; PI3K, phosphatidylinositol 3-phosphate kinase; SOCS, suppressor of cytokine signaling; T2DM, type 2 diabetes mellitus; Tg, transgenic; USP; USP, ubiquitin-specific protease; pAkt, phosphorylated Akt; pIRß, phosphorylated insulin receptor ß chain

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Biochem Biophys Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão País de publicação: Holanda

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