[Pharmacokinetics of gypenoside XVâ
¡ in rats].
Zhongguo Zhong Yao Za Zhi
; 42(4): 783-788, 2017 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-28959853
ABSTRACT
In this study, we established an HPLC-MS method to determine gypenoside XVâ
¡ in biosamples. The methodology results indicated that the linear range was 1-2 500 µgâ¢L⻹ (r=0.996 3); intraday RSD values for high, medium and low concentrations were 9.9%, 3.0% 1.7%; interday RSD values were 16%, 14%, 2.5%; matrix effect ranged between 90.0%-100%, with RSD<15%. The recovery was more than 80.0%, with precision and accuracy in line with request. After the rats were orally and intravenously administered with gypenoside XVâ
¡, the concentrations of gypenoside XVâ
¡ in plasma were determined, and pharmacokinetic parameter was calculated using pharmacokinetic software DAS 2.0. According to the main pharmacokinetic parameters of gypenoside XVâ
¡, tmax was 0.17-0.20 h, t1/2 was 1.94-2.56 h, bioavailability of oral administration was 1.87%. The results indicated that the pharmacokinetic profiles of gypenoside XVâ
¡ were rapid absorption and distribution after oral administration, short time to peak and rapid elimination.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gynostemma
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China