Homologous plant and bacterial proteins chaperone oligomeric protein assembly.
Nature
; 333(6171): 330-4, 1988 May 26.
Article
em En
| MEDLINE
| ID: mdl-2897629
ABSTRACT
An abundant chloroplast protein is implicated in the assembly of the oligomeric enzyme ribulose bisphosphate carboxylase-oxygenase, which catalyses photosynthetic CO2-fixation in higher plants. The product of the Escherichia coli groEL gene is essential for cell viability and is required for the assembly of bacteriophage capsids. Sequencing of the groEL gene and the complementary cDNA encoding the chloroplast protein has revealed that these proteins are evolutionary homologues which we term 'chaperonins'. Chaperonins comprise a class of molecular chaperones that are found in chloroplasts, mitochondria and prokaryotes. Assisted post-translational assembly of oligomeric protein structures is emerging as a general cellular phenomenon.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas
/
Ribulose-Bifosfato Carboxilase
/
Proteínas de Bactérias
/
Adenosina Trifosfatases
/
Escherichia coli
/
Genes
/
Genes Bacterianos
/
Proteínas de Choque Térmico
Idioma:
En
Revista:
Nature
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Canadá