[Effect of psychotropic preparations on the properties of tubulin in the brain]. / Vliianie psikhotropnykh preparatov na svoistva tubulina mozga.
Zh Nevropatol Psikhiatr Im S S Korsakova
; 88(5): 119-23, 1988.
Article
em Ru
| MEDLINE
| ID: mdl-2901178
ABSTRACT
Neuroleptics (chlorpromazine, triftazin, haloperidol) inhibited the tubulin polymerization on supernatant of rat brain proteins in vivo at concentrations which corresponded to the therapeutic ones. The electron microscope studies demonstrated that these drugs inhibited the assembly of tubulin in microtubules. As this effect was the same in vivo and in vitro, it was considered specific. Colchicine-binding capacity of tubulin was suppressed only at higher doses of tranquilizers (250 microM). Antidepressant drug melipramine inhibited neither tubulin polymerization in vivo nor its colchicine-binding activity in vivo or in vitro.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psicotrópicos
/
Tubulina (Proteína)
/
Encéfalo
Limite:
Animals
Idioma:
Ru
Revista:
Zh Nevropatol Psikhiatr Im S S Korsakova
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
1988
Tipo de documento:
Article